Vk Gene Repertoire and Locus Contraction Are Specified by Critical DNase I Hypersensitive Sites within the Vk-Jk Intervening Region
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منابع مشابه
A Multifunctional Element in the Mouse Igk Locus That Specifies Repertoire and Ig Loci Subnuclear Location
Nonbiased V gene usage for V(D)J joining is essential for providing an optimal immune system, but no cis-acting sequence with this function has been uncovered. We previously identified a recombination silencer and heterochromatin targeting element in the Vk-Jk intervening sequence of germline Igk transgenes, which we termed Sis. We now have generated Sis knockout mice in the endogenous locus. I...
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During the developmental progression of lymphoid progenitors, antigen receptor loci are assembled from variable (V), diversity (D), and joining (J) gene segments. In precursor B cells, the immunoglobulin heavy chain (Igh) locus undergoes ordered gene segment rearrangement with D H J H joining preceding V H to D H J H rearrangement. Similarly, in progenitor T lineage cells, the T cell receptor b...
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تاریخ انتشار 2013